Gangrenous Chickenpox with Atypical Clinical and Histopathological Findings
نویسندگان
چکیده
Varicella (chickenpox) is a highly contagious disease caused by varicella zoster virus (VZV). The primary infection results in acute varicella with fever, malaise, and a widely disseminated vesicular and itching rash, frequently solving with scars. The rash begins on the face, scalp, and trunk and occurs in crops; typically, lesions are at different stages of evolution. The oral mucous membrane is frequently involved, with small painful ulcers [1]. Histopathology is characterized by intraepidermal blister, acantholysis or necrosis of the epithelium, and lymphoid infiltrates. Infected cells show characteristic viral cytopathic effects with ballooning degeneration, eosinophilic cytoplasmic inclusions, and glassy, eosinophilic, nuclear inclusions with marginated chromatin, often with multiple nuclei [2].
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